Hi and thank you for your question! Resistance to Botox is rare but I have seen it in a few of my patients who gradually need more units to see the same response and it is often attributed to resistance/immunity to Botox. In such cases, some patients may respond better when switching to other neuromodulators, so you can try Jeuveau (or Dysport/Xeomin) and hopefully you will see better results. I hope it helps and good luck!
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